Title : Hypospadias risk and polymorphism in SRD5A2 and CYP17 genes: case-control study among Indian children.

Pub. Date : 2011 Jun

PMID : 21511288






1 Functional Relationships(s)
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1 As androgens have a significant role in the development of the male urethra, we sought to investigate the association between 2 functional polymorphisms, CYP17-A1/A2 and SRD5A2-V89L, which are involved in the biosynthesis of testosterone and dihydrotestosterone, respectively, in relation to hypospadias. Testosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens