Pub. Date : 2011 Apr
PMID : 21508359
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BON. | Serotonin | phosphatase and tensin homolog | Homo sapiens |
| 2 | The purpose of this study was to investigate the relationship between the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome ten) and serotonin synthesis and secretion in the carcinoid cancer cell line BON. | Serotonin | phosphatase and tensin homolog | Homo sapiens |
| 3 | MATERIALS AND METHODS: PTEN was inhibited by pharmacological and molecular approaches, and the resultant secretion of serotonin and expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, was assessed. | Serotonin | phosphatase and tensin homolog | Homo sapiens |
| 4 | MATERIALS AND METHODS: PTEN was inhibited by pharmacological and molecular approaches, and the resultant secretion of serotonin and expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, was assessed. | Serotonin | phosphatase and tensin homolog | Homo sapiens |
| 5 | RESULTS: Inhibition of PTEN in vitro, with concomitant increased Akt signaling, resulted in decreased secretion of serotonin, as well as decreased serotonin synthesis, as confirmed by reduced expression of TPH1. | Serotonin | phosphatase and tensin homolog | Homo sapiens |
| 6 | RESULTS: Inhibition of PTEN in vitro, with concomitant increased Akt signaling, resulted in decreased secretion of serotonin, as well as decreased serotonin synthesis, as confirmed by reduced expression of TPH1. | Serotonin | phosphatase and tensin homolog | Homo sapiens |
| 7 | Inhibition of PTEN in BON cells in an animal model resulted in decreased serum serotonin. | Serotonin | phosphatase and tensin homolog | Homo sapiens |
| 8 | CONCLUSION: By inhibiting signaling through Akt, PTEN indirectly promotes serotonin synthesis and secretion. | Serotonin | phosphatase and tensin homolog | Homo sapiens |