Title : Shifting topographic activation and 5-HT1A receptor-mediated inhibition of dorsal raphe serotonin neurons produced by nicotine exposure and withdrawal.

Pub. Date : 2011 May

PMID : 21501256






4 Functional Relationships(s)
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1 Shifting topographic activation and 5-HT1A receptor-mediated inhibition of dorsal raphe serotonin neurons produced by nicotine exposure and withdrawal. Nicotine 5-hydroxytryptamine receptor 1A Homo sapiens
2 Previous chronic nicotine exposure did not modify the pattern of activation produced by acute nicotine exposure, but increased 5-HT1A receptor-dependent inhibition of 5-HT cells in the caudal DR. Nicotine 5-hydroxytryptamine receptor 1A Homo sapiens
3 This pattern was nearly reversed during nicotine withdrawal, when there was evidence for caudal activation and mid-level and rostral 5-HT1A receptor-dependent inhibition. Nicotine 5-hydroxytryptamine receptor 1A Homo sapiens
4 These results suggest that the distinct behavioral states produced by nicotine exposure and withdrawal correlate with reciprocal rostral-caudal patterns of activation and 5-HT1A receptor-mediated inhibition of DR 5-HT neurons. Nicotine 5-hydroxytryptamine receptor 1A Homo sapiens