PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21501256-0 2011 Shifting topographic activation and 5-HT1A receptor-mediated inhibition of dorsal raphe serotonin neurons produced by nicotine exposure and withdrawal. Nicotine 118-126 5-hydroxytryptamine receptor 1A Homo sapiens 36-51 21501256-7 2011 Previous chronic nicotine exposure did not modify the pattern of activation produced by acute nicotine exposure, but increased 5-HT1A receptor-dependent inhibition of 5-HT cells in the caudal DR. Nicotine 17-25 5-hydroxytryptamine receptor 1A Homo sapiens 127-142 21501256-8 2011 This pattern was nearly reversed during nicotine withdrawal, when there was evidence for caudal activation and mid-level and rostral 5-HT1A receptor-dependent inhibition. Nicotine 40-48 5-hydroxytryptamine receptor 1A Homo sapiens 133-148 21501256-9 2011 These results suggest that the distinct behavioral states produced by nicotine exposure and withdrawal correlate with reciprocal rostral-caudal patterns of activation and 5-HT1A receptor-mediated inhibition of DR 5-HT neurons. Nicotine 70-78 5-hydroxytryptamine receptor 1A Homo sapiens 171-186