Pub. Date : 2011 Aug
PMID : 21501147
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-gamma. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | The purpose of the present study was to determine whether PPARgamma, an important nuclear receptor, mediates 2-AG-induced inhibition of NF-kappaB phosphorylation and COX-2 expression, and COX-2-enhanced miniature spontaneous excitatory postsynaptic currents (mEPSCs). | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | KEY RESULTS: Exogenous and endogenous 2-AG-produced suppressions of NF-kappaB-p65 phosphorylation, COX-2 expression and excitatory synaptic transmission in response to pro-inflammatory interleukin-1beta (IL-1beta) and LPS were inhibited by GW9662, a selective PPARgamma antagonist, in hippocampal neurons in culture. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | PPARgamma agonists 15-deoxy-Delta(12,14) -prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone mimicked the effects of 2-AG on NF-kappaB-p65 phosphorylation, COX-2 expression and mEPSCs, and these effects were eliminated by antagonism of PPARgamma. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | PPARgamma agonists 15-deoxy-Delta(12,14) -prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone mimicked the effects of 2-AG on NF-kappaB-p65 phosphorylation, COX-2 expression and mEPSCs, and these effects were eliminated by antagonism of PPARgamma. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 6 | Moreover, exogenous application of 2-AG or elevation of endogenous 2-AG by inhibiting its hydrolysis with URB602 or JZL184, selective inhibitors of monoacylglycerol lipase (MAGL), prevented the IL-1beta- and LPS-induced reduction of PPARgamma expression. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 7 | Moreover, exogenous application of 2-AG or elevation of endogenous 2-AG by inhibiting its hydrolysis with URB602 or JZL184, selective inhibitors of monoacylglycerol lipase (MAGL), prevented the IL-1beta- and LPS-induced reduction of PPARgamma expression. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 8 | CONCLUSIONS AND IMPLICATIONS: Our results suggest that CB(1) receptor-dependent PPARgamma expression is an important and novel signalling pathway in endocannabinoid 2-AG-produced resolution of neuroinflammation in response to pro-inflammatory insults. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |