Title : Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification.

Pub. Date : 2011 Sep 29

PMID : 21499301






1 Functional Relationships(s)
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1 Lapatinib induced apoptosis in association with upregulation of the pro-apoptotic protein Bcl-2 interacting mediator of cell death (BIM) through inhibition of the MEK-ERK signaling pathway in breast cancer cells with HER2 amplification. Lapatinib mitogen-activated protein kinase kinase 7 Homo sapiens