Title : EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells.

Pub. Date : 2011 May

PMID : 21499124






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands. Quercetin epidermal growth factor receptor Homo sapiens
2 As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands. Quercetin epidermal growth factor receptor Homo sapiens