Title : Does erlotinib restore chemosensitivity to chemotherapy in pancreatic cancer? A case series.

Pub. Date : 2011 Mar

PMID : 21498735






4 Functional Relationships(s)
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1 In preclinical models, exposure of pancreatic cancer cell lines to an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor plus gemcitabine suggested enhanced cytotoxicity of gemcitabine and induced apoptosis in tumor cells. gemcitabine epidermal growth factor receptor Homo sapiens
2 In preclinical models, exposure of pancreatic cancer cell lines to an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor plus gemcitabine suggested enhanced cytotoxicity of gemcitabine and induced apoptosis in tumor cells. gemcitabine epidermal growth factor receptor Homo sapiens
3 Erlotinib inhibited gemcitabine-induced phosphorylation of EGFR, which may promote cytotoxicity from gemcitabine. gemcitabine epidermal growth factor receptor Homo sapiens
4 Erlotinib inhibited gemcitabine-induced phosphorylation of EGFR, which may promote cytotoxicity from gemcitabine. gemcitabine epidermal growth factor receptor Homo sapiens