Pub. Date : 2011 Sep
PMID : 21496491
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-kappaB mediated inflammatory pathways. | ursolic acid | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. | ursolic acid | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-kappaB signaling pathways. | ursolic acid | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |