Title : A model of a MAPK•substrate complex in an active conformation: a computational and experimental approach.

Pub. Date : 2011 Apr 11

PMID : 21494553






1 Functional Relationships(s)
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1 The computer-generated model was used to guide mutagenesis experiments, which support the notion that Leu-11 and possibly Ile-13 and Ile-14 of Ets-1 1-138 (Ets) make contributions through binding to the hydrophobic groove of the ERK2 D-recruiting site (DRS). Leucine mitogen-activated protein kinase 1 Homo sapiens