Title : Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.

Pub. Date : 2011 May

PMID : 21493161






5 Functional Relationships(s)
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1 Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy. Carbamazepine ATP binding cassette subfamily B member 1 Homo sapiens
2 We sought to investigate the effects of ABCB1 polymorphisms on plasma carbamazepine (CBZ) concentrations and pharmacoresistance in Chinese patients with epilepsy. Carbamazepine ATP binding cassette subfamily B member 1 Homo sapiens
3 We sought to investigate the effects of ABCB1 polymorphisms on plasma carbamazepine (CBZ) concentrations and pharmacoresistance in Chinese patients with epilepsy. Carbamazepine ATP binding cassette subfamily B member 1 Homo sapiens
4 C1236T, G2677T/A, and C3435T polymorphisms of ABCB1 were genotyped by polymerase chain reaction amplification followed by restriction fragment length polymorphism analysis or direct automated DNA sequencing in 84 patients treated with CBZ monotherapy. Carbamazepine ATP binding cassette subfamily B member 1 Homo sapiens
5 Our results suggest that ABCB1 3435-TT is associated with decreased plasma CBZ levels in Chinese patients with epilepsy. Carbamazepine ATP binding cassette subfamily B member 1 Homo sapiens