Pub. Date : 2011 Apr 14
PMID : 21492444
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estrogen receptor beta represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity. | Tamoxifen | estrogen receptor 2 | Homo sapiens |
| 2 | Expression of ERbeta in breast tumors has been implicated as an indicator of tamoxifen sensitivity. | Tamoxifen | estrogen receptor 2 | Homo sapiens |
| 3 | Importantly, ERbeta expression increased the sensitivity of these breast cancer cells to tamoxifen. | Tamoxifen | estrogen receptor 2 | Homo sapiens |
| 4 | CONCLUSIONS: Our results suggest a link between expression of ERbeta and endocrine sensitivity by increasing PTEN levels and decreasing HER2/HER3 signaling, thereby reducing Akt signaling with subsequent effects on proliferation, survival and tamoxifen sensitivity of breast cancer cells. | Tamoxifen | estrogen receptor 2 | Homo sapiens |