Pub. Date : 2011 Jun
PMID : 21490593
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to determine whether formation clearance (CL(f)) of the sum of 6beta-hydroxycortisol and 6beta-hydroxycortisone is a useful probe of CYP3A4 inhibition in vivo. | 6 beta-hydroxycortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In human liver microsomes (HLMs), the formation of 6beta-hydroxycortisol and 6beta-hydroxycortisone was catalyzed by CYP3A4, and itraconazole inhibited these reactions with half maximal inhibitory concentration (IC(50))(,u) values of 3.1 nmol/l and 3.4 nmol/l, respectively. | 6 beta-hydroxycortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |