Pub. Date : 2011 May
PMID : 21488184
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Jun NH2-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | Dexmedetomidine-induced phosphorylation of ERK, JNK, and p38 MAPK in rat aortic SMCs was detected using Western blotting. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | Dexmedetomidine induced phosphorylation of JNK and p38 MAPK in rat aortic SMCs, but did not induce phosphorylation of ERK. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | CONCLUSION: Dexmedetomidine-induced contraction involves a JNK- and p38 MAPK-mediated pathway downstream of alpha2-adrenoceptor stimulation in rat aortic SMCs. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |