Title : In vitro investigation of human UDP-glucuronosyltransferase isoforms responsible for tacrolimus glucuronidation: predominant contribution of UGT1A4.

Pub. Date : 2011 Jul

PMID : 21487055






2 Functional Relationships(s)
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Protein Name
Organism
1 This conclusion is supported by the finding of inhibition with a specific substrate of UGT1A4 lamotrigine with K(i) values similar for both human liver and UGT1A4 microsomes and the correlation with trifluoperazine-glucuronide formation by liver microsomes (r(s) = 0.551; p = 0.02). Lamotrigine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 This conclusion is supported by the finding of inhibition with a specific substrate of UGT1A4 lamotrigine with K(i) values similar for both human liver and UGT1A4 microsomes and the correlation with trifluoperazine-glucuronide formation by liver microsomes (r(s) = 0.551; p = 0.02). Lamotrigine UDP glucuronosyltransferase family 1 member A4 Homo sapiens