Title : IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.

Pub. Date : 2011 Apr 15

PMID : 21487040






1 Functional Relationships(s)
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1 At the functional level, inhibition of A-CDase activity, silencing A-CDase expression, or application of exogenous C16 ceramide sensitized CML cells to FasL-induced apoptosis, whereas overexpression of A-CDase decreased CML cells" sensitivity to FasL-induced apoptosis. Ceramides Fas ligand Homo sapiens