CPRiL

FASLG

Fas ligand

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

• tumor necrosis factor ligand superfamily member 6
• CD95 ligand
• Fas ligand (TNF superfamily, member 6)
apoptosis (APO-1) antigen ligand 1
apoptosis antigen ligand
fas antigen ligand
mutant tumor necrosis factor family member 6
tumor necrosis factor ligand 1A
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
TNLG1A