Protein Name Fas ligand
Organism Homo sapiens
Gene ID 356
Gene Symbol


UniProt P48023 (TNFL6_HUMAN), Q53ZZ1 (Q53ZZ1_HUMAN)
Relationships Total Number of functionally related compound(s) : 783
Total Number of Articles : 1361

Fas ligand

Gene Summary

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

  • tumor necrosis factor ligand superfamily member 6
  • CD95 ligand
  • Fas ligand (TNF superfamily, member 6)
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