Title : Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention.

Pub. Date : 2011 Jun 1

PMID : 21487034






3 Functional Relationships(s)
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1 Here we show that Nrf2 faces a dilemma in defense against 4-aminobiphenyl (ABP), a major human bladder carcinogen from tobacco smoke and other environmental sources. 4-biphenylamine NFE2 like bZIP transcription factor 2 Homo sapiens
2 Here we show that Nrf2 faces a dilemma in defense against 4-aminobiphenyl (ABP), a major human bladder carcinogen from tobacco smoke and other environmental sources. 4-biphenylamine NFE2 like bZIP transcription factor 2 Homo sapiens
3 These findings raise concerns of potential bladder toxicity when Nrf2-activating chemopreventive agents are used in humans exposed to ABP, especially in smokers. 4-biphenylamine NFE2 like bZIP transcription factor 2 Homo sapiens