Pub. Date : 2011 Jun 1
PMID : 21482676
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In a mouse model of mammary carcinoma driven by the polyomavirus middle T (PyVmT) oncogene, the ErbB2 tyrosine kinase inhibitor lapatinib reduced the activation of ErbB3 and Akt as well as tumor cell growth. | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 2 | In this phosphatidylinositol-3 kinase (PI3K)-dependent tumor model, ErbB2 is part of a complex containing PyVmT, p85 (PI3K), and ErbB3, that is disrupted by treatment with lapatinib. | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |