Pub. Date : 2011 Apr 7
PMID : 21472003
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Conversely, enforced activation of Akt by a constitutively active Akt construct markedly abrogated PEITC-mediated JNK activation, Mcl-1 downregulation, caspase activation, and apoptosis, and also interruption of the JNK pathway by pharmacological or genetically (e.g., siRNA) attenuated PEITC-induced apoptosis. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Conversely, enforced activation of Akt by a constitutively active Akt construct markedly abrogated PEITC-mediated JNK activation, Mcl-1 downregulation, caspase activation, and apoptosis, and also interruption of the JNK pathway by pharmacological or genetically (e.g., siRNA) attenuated PEITC-induced apoptosis. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Finally, administration of PEITC markedly inhibited tumor growth and induced apoptosis in U937 xenograft model in association with inactivation of Akt, activation of JNK, as well as downregulation of Mcl-1. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Taken together, these findings represent a novel mechanism by which agents targeting Akt/JNK/Mcl-1 pathway potentiate PEITC lethality in transformed and primary human leukemia cells and inhibitory activity of tumor growth of U937 xenograft model. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |