Title : Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome.

Pub. Date : 2011 Jun 15

PMID : 21464611






2 Functional Relationships(s)
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1 Here we demonstrate that doxorubicin induces a systemic increase in IL-1beta and other inflammatory cytokines, chemokines and growth factors including TNF-alpha, IL-6, CXCL1/Gro-alpha, CCL2/MCP-1, granulocyte colony stimulating factor (GCSF), and CXCL10/IP-10. Doxorubicin interleukin 6 Mus musculus
2 Studies with IL-1R-deficient mice demonstrate that IL-1 signaling plays a role in doxorubicin-induced increases in IL-6 and GCSF. Doxorubicin interleukin 6 Mus musculus