Title : The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models.

Pub. Date : 2011 May 15

PMID : 21464044






1 Functional Relationships(s)
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1 Lapatinib is an EGFR/HER2 kinase inhibitor suppressing signaling through the RAS/RAF/MEK (MAP/ERK kinase)/MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase)/AKT pathways. Lapatinib mitogen-activated protein kinase kinase 7 Homo sapiens