Title : Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide.

Pub. Date : 2011 Sep

PMID : 21463481






2 Functional Relationships(s)
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1 Our previous studies demonstrated that dual inhibition of iNOS and COX with a selective COX-2 inhibitor, NS-398, or a non-selective COX inhibitor, indomethacin, restores blood pressure presumably because of increased production of 20-hydroxyeicosatetraenoic acid (20-HETE) derived from arachidonic acid (AA) by CYP4A in endotoxaemic rats. 20-hydroxy-5,8,11,14-eicosatetraenoic acid nitric oxide synthase 2 Rattus norvegicus
2 Our previous studies demonstrated that dual inhibition of iNOS and COX with a selective COX-2 inhibitor, NS-398, or a non-selective COX inhibitor, indomethacin, restores blood pressure presumably because of increased production of 20-hydroxyeicosatetraenoic acid (20-HETE) derived from arachidonic acid (AA) by CYP4A in endotoxaemic rats. 20-hydroxy-5,8,11,14-eicosatetraenoic acid nitric oxide synthase 2 Rattus norvegicus