Title : Ethanol inhibits lipid raft-mediated TCR signaling and IL-2 expression: potential mechanism of alcohol-induced immune suppression.

Pub. Date : 2011 Aug

PMID : 21463338






2 Functional Relationships(s)
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Protein Name
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1 Ethanol decreases tyrosine phosphorylation and activation of upstream signaling proteins PLCgamma1, LAT, ZAP70, and Lck. Ethanol phospholipase C gamma 1 Homo sapiens
2 Sucrose density gradient fractionation and confocal microscopy revealed that ethanol inhibited essential upstream lipid raft-mediated TCR-dependent signaling events, namely colocalization of Lck, ZAP70, LAT, and PLCgamma1 with plasma membrane lipid rafts. Ethanol phospholipase C gamma 1 Homo sapiens