Title : Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease.

Pub. Date : 2010

PMID : 21461045






4 Functional Relationships(s)
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1 These results suggest that isoflavones have other mechanisms of action, potentially those involving regulation of fatty acid metabolism via the nuclear receptors PPARalpha and PPARgamma. Isoflavones peroxisome proliferator activated receptor alpha Homo sapiens
2 The goal of this paper was to examine the evidence for isoflavone/PPAR signaling and to identify diseases in which such signaling would have an important impact. Isoflavones peroxisome proliferator activated receptor alpha Homo sapiens
3 It is therefore of note that investigators using a chemical structure approach to discover PPAR ligands identified isoflavones as the best structures in the library of compounds that they tested. Isoflavones peroxisome proliferator activated receptor alpha Homo sapiens
4 Future studies will involve careful identification of the underlying mechanisms whereby isoflavones have their action via PPAR signaling. Isoflavones peroxisome proliferator activated receptor alpha Homo sapiens