Title : Long-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene.

Pub. Date : 2012 Feb 15

PMID : 21445973






2 Functional Relationships(s)
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1 Long-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene. Sunitinib phosphatase and tensin homolog Homo sapiens
2 Notably, forced-expression of PTEN in GIST-T1R cells negatively regulated the Akt/mTOR pathways and sensitized these cells to sunitinib-mediated growth arrest and apoptosis. Sunitinib phosphatase and tensin homolog Homo sapiens