Title : Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring.

Pub. Date : 2012 Jul

PMID : 21440054






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1 The results showed that maternal exposure to 2.0mg/kgd PFOS caused severe histopathological changes along with marked oxidative injuries and cell apoptosis in offspring lungs; at the same time, the ratio of Bax to Bcl-2, release of cytochrome c (Cyt c) from mitochondria to cytoplasm, expressions of Fas and Fas-L, and activities of caspase-3, -8 and -9 were up-regulated correspondingly. perfluorooctane sulfonic acid BCL2, apoptosis regulator Rattus norvegicus