Title : Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis.

Pub. Date : 2011 Jun

PMID : 21433042






3 Functional Relationships(s)
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1 Live cell imaging of GFPp65/RelA showed that diclofenac dampened the TNF-alpha-mediated nuclear factor kappaB (NF-kappaB) translocation oscillation in association with reduced NF-kappaB transcriptional activity. Diclofenac nuclear factor kappa B subunit 1 Homo sapiens
2 Live cell imaging of GFPp65/RelA showed that diclofenac dampened the TNF-alpha-mediated nuclear factor kappaB (NF-kappaB) translocation oscillation in association with reduced NF-kappaB transcriptional activity. Diclofenac nuclear factor kappa B subunit 1 Homo sapiens
3 This was associated with inhibition by diclofenac of the TNF-alpha-induced phosphorylation of the inhibitor of NF-kappaB alpha (IkappaBalpha). Diclofenac nuclear factor kappa B subunit 1 Homo sapiens