Pub. Date : 2011 Mar 19
PMID : 21418583
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 2 | MG132 in combination with resveratrol caused cell cycle blockade at G1/S transition via p27Kip1 accumulation. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 3 | Knockdown of p27Kip1 using siRNA dramatically attenuated the protective effects of resveratrol on cytotoxic actions of proteasome inhibitors against leukemic cells. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 4 | MG132 in combination with resveratrol caused synergistic induction of p27Kip1 through increased recruitment of FOXO1 on the p27Kip1 promoter. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 5 | MG132 in combination with resveratrol caused synergistic induction of p27Kip1 through increased recruitment of FOXO1 on the p27Kip1 promoter. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |
| 6 | CONCLUSIONS: Resveratrol may have the potential to negate the cytotoxic effects of proteasome inhibitors via regulation of FOXO1 transcriptional activity and accumulation of p27Kip1. | Resveratrol | cyclin dependent kinase inhibitor 1B | Homo sapiens |