Title : Azithromycin may inhibit interleukin-8 through suppression of Rac1 and a nuclear factor-kappa B pathway in KB cells stimulated with lipopolysaccharide.

Pub. Date : 2011 Nov

PMID : 21417583






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Therefore, we investigated the effects of AZM on IL-8 production in an oral epithelial cell line. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
2 RESULTS: IL-8 mRNA expression, IL-8 production, and NF-kappaB activation in LPS-stimulated KB cells were inhibited by the addition of AZM. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
3 RESULTS: IL-8 mRNA expression, IL-8 production, and NF-kappaB activation in LPS-stimulated KB cells were inhibited by the addition of AZM. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
4 CONCLUSIONS: This study suggests that AZM inhibits LPS-induced IL-8 production in an oral epithelial cell line, in part caused by the suppression of Rac1 and NF-kappaB activation. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens