Title : Lamotrigine protects against kainate but not ibotenate lesions in rat striatum.

Pub. Date : 1990 May 4

PMID : 2141673






1 Functional Relationships(s)
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1 Pretreatment of rats with 8-16 mg/kg of lamotrigine 1 h before intrastriatal injections of 2 nm of kainic acid significantly attenuated the neurotoxicity as evidenced by measurements of striatal choline acetyltransferase and glutamate decarboxylase activities. Lamotrigine choline O-acetyltransferase Rattus norvegicus