Pub. Date : 2011 Apr 15
PMID : 21414301
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells. | celastrol | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Celastrol induced Nrf2 activation. | celastrol | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Nrf2 knockdown using small interfering RNA (siRNA) inhibited celastrol-induced HO-1 expression. | celastrol | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Furthermore, Nrf2 siRNA significantly reversed the inhibitory effect of celastrol on IFN-gamma-induced expression of ICAM-1 in the keratinocytes. | celastrol | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | Taken together, our results indicate that celastrol can activate the ROS-ERK/p38-Nrf2-ARE signaling cascades leading to the up-regulation of HO-1 which is partly responsible for its anti-inflammatory activity in the keratinocytes. | celastrol | NFE2 like bZIP transcription factor 2 | Homo sapiens |