Pub. Date : 2011 May 2
PMID : 21406211
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, the alterations in gene expression of nAChR subunits using an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model remain unclear. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | However, the alterations in gene expression of nAChR subunits using an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model remain unclear. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | In the present study, we profile the time course of nAChR alpha7, alpha4 and beta2 subunit expression levels using a comparative RT-PCR approach after acute MPTP injection. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | In the present study, we profile the time course of nAChR alpha7, alpha4 and beta2 subunit expression levels using a comparative RT-PCR approach after acute MPTP injection. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 5 | (1) MPTP treatment transiently increased nAChR alpha7 (after last injection of MPTP 3 and 24 h), alpha4 and beta2 (24 h) mRNA expression in the substantia nigra (SN) and striatum. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 6 | (1) MPTP treatment transiently increased nAChR alpha7 (after last injection of MPTP 3 and 24 h), alpha4 and beta2 (24 h) mRNA expression in the substantia nigra (SN) and striatum. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 7 | (3) In the acute MPTP model, time-courses of altered expression for nAChR alpha7, alpha4 and beta2 subunits closely mirrored the deficits observed in animal motor activity. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 8 | (3) In the acute MPTP model, time-courses of altered expression for nAChR alpha7, alpha4 and beta2 subunits closely mirrored the deficits observed in animal motor activity. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 9 | These changes followed or paralleled MPTP-induced elevation in the levels of alpha7, alpha4 and beta2 mRNAs. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |