Pub. Date : 2011 Feb
PMID : 21403840
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrate that, among a panel of pediatric sarcomas, Ewing sarcoma family of tumors (ESFTs) cell lines bearing the EWS-FLI1 transcription factor are the most sensitive to treatment with ET-743 compared with osteosarcoma, rhabdomyosarcoma, and synovial sarcoma. | Trabectedin | Fli-1 proto-oncogene, ETS transcription factor | Homo sapiens |
| 2 | We show that ET-743 reverses a gene signature of induced downstream targets of EWS-FLI1 in two different ESFT cell lines (P = .001). | Trabectedin | Fli-1 proto-oncogene, ETS transcription factor | Homo sapiens |
| 3 | In addition, ET-743 directly suppresses the promoter activity of a known EWS-FLI1 downstream target NR0B1 luciferase reporter construct without changing the activity of a constitutively active control in ESFT cells. | Trabectedin | Fli-1 proto-oncogene, ETS transcription factor | Homo sapiens |
| 4 | Furthermore, the effect is specific to EWS-FLI1, as forced expression of EWS-FLI1 in a cell type that normally lacks this fusion protein, HT1080 cells, induces the same NR0B1 promoter, but this activation is completely blocked by ET-743 treatment. | Trabectedin | Fli-1 proto-oncogene, ETS transcription factor | Homo sapiens |
| 5 | Furthermore, the effect is specific to EWS-FLI1, as forced expression of EWS-FLI1 in a cell type that normally lacks this fusion protein, HT1080 cells, induces the same NR0B1 promoter, but this activation is completely blocked by ET-743 treatment. | Trabectedin | Fli-1 proto-oncogene, ETS transcription factor | Homo sapiens |