Title : Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping.

Pub. Date : 2011 Mar

PMID : 21403766






1 Functional Relationships(s)
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1 To probe the origin and structure of this radical, we combined EPR analysis with nitric oxide (NO) trapping of tyrosine and substrate derived radicals for both PGHS-1 and -2. Nitric Oxide prostaglandin-endoperoxide synthase 1 Homo sapiens