Title : Phosphatidylserine is a critical modulator for Akt activation.

Pub. Date : 2011 Mar 21

PMID : 21402788






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. pip(3) AKT serine/threonine kinase 1 Homo sapiens
2 Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. pip(3) AKT serine/threonine kinase 1 Homo sapiens
3 Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS). pip(3) AKT serine/threonine kinase 1 Homo sapiens
4 PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2. pip(3) AKT serine/threonine kinase 1 Homo sapiens
5 PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2. pip(3) AKT serine/threonine kinase 1 Homo sapiens
6 These data identify a critical function of PS for Akt activation and cell survival, particularly in conditions with limited PIP(3) availability. pip(3) AKT serine/threonine kinase 1 Homo sapiens