Pub. Date : 2011 Mar 21
PMID : 21402788
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. | pip(3) | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. | pip(3) | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS). | pip(3) | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2. | pip(3) | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2. | pip(3) | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | These data identify a critical function of PS for Akt activation and cell survival, particularly in conditions with limited PIP(3) availability. | pip(3) | AKT serine/threonine kinase 1 | Homo sapiens |