PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21402788-1 2011 Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. pip(3) 89-95 AKT serine/threonine kinase 1 Homo sapiens 0-3 21402788-1 2011 Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. pip(3) 89-95 AKT serine/threonine kinase 1 Homo sapiens 40-43 21402788-2 2011 Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS). pip(3) 59-65 AKT serine/threonine kinase 1 Homo sapiens 26-29 21402788-4 2011 PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2. pip(3) 16-22 AKT serine/threonine kinase 1 Homo sapiens 12-15 21402788-4 2011 PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2. pip(3) 48-54 AKT serine/threonine kinase 1 Homo sapiens 63-66 21402788-7 2011 These data identify a critical function of PS for Akt activation and cell survival, particularly in conditions with limited PIP(3) availability. pip(3) 124-130 AKT serine/threonine kinase 1 Homo sapiens 50-53