PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21402788-1	2011	Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane.	pip(3)	89-95	AKT serine/threonine kinase 1	Homo sapiens	0-3	
21402788-1	2011	Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane.	pip(3)	89-95	AKT serine/threonine kinase 1	Homo sapiens	40-43	
21402788-2	2011	Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS).	pip(3)	59-65	AKT serine/threonine kinase 1	Homo sapiens	26-29	
21402788-4	2011	PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2.	pip(3)	16-22	AKT serine/threonine kinase 1	Homo sapiens	12-15	
21402788-4	2011	PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2.	pip(3)	48-54	AKT serine/threonine kinase 1	Homo sapiens	63-66	
21402788-7	2011	These data identify a critical function of PS for Akt activation and cell survival, particularly in conditions with limited PIP(3) availability.	pip(3)	124-130	AKT serine/threonine kinase 1	Homo sapiens	50-53