Title : Protective role of a coumarin-derived schiff base scaffold against tertiary butyl hydroperoxide (TBHP)-induced oxidative impairment and cell death via MAPKs, NF-κB and mitochondria-dependent pathways.

Pub. Date : 2011 May

PMID : 21391895






2 Functional Relationships(s)
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1 Protective role of a coumarin-derived schiff base scaffold against tertiary butyl hydroperoxide (TBHP)-induced oxidative impairment and cell death via MAPKs, NF-kappaB and mitochondria-dependent pathways. tert-Butylhydroperoxide nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 TBHP also activated phospho-ERK1/2, phospho-p38 and NF-kappaB, altered the Bcl-2/Bad ratio, reduced mitochondrial membrane potential, released cytochrome C and activated caspase 3, suggesting that TBHP induced oxidative stress responsive cell death via apoptotic pathway. tert-Butylhydroperoxide nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus