Pub. Date : 2011 May 15
PMID : 21389782
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potent genistein derivatives as inhibitors of estrogen receptor alpha-positive breast cancer. | Genistein | estrogen receptor 1 | Homo sapiens |
| 2 | In our analysis, we noticed that at IC(50) concentrations, the MA-6, MA-8 and MA-19 Genistein derivatives induced apoptosis, inhibited ER-alpha messenger RNA expression and increased the ratio of ER-beta to ER-alpha levels in a manner comparable to the parent compound Genistein. | Genistein | estrogen receptor 1 | Homo sapiens |
| 3 | In our analysis, we noticed that at IC(50) concentrations, the MA-6, MA-8 and MA-19 Genistein derivatives induced apoptosis, inhibited ER-alpha messenger RNA expression and increased the ratio of ER-beta to ER-alpha levels in a manner comparable to the parent compound Genistein. | Genistein | estrogen receptor 1 | Homo sapiens |
| 4 | Of note, these three modified Genistein derivatives exerted their effects at concentrations 10-15 times lower than the parent compound, decreasing the likelihood of significant ER- alpha pathway activation, which has been a concern for Genistein. | Genistein | estrogen receptor 1 | Homo sapiens |
| 5 | Of note, these three modified Genistein derivatives exerted their effects at concentrations 10-15 times lower than the parent compound, decreasing the likelihood of significant ER- alpha pathway activation, which has been a concern for Genistein. | Genistein | estrogen receptor 1 | Homo sapiens |