Title : Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins.

Pub. Date : 2011 Jun 1

PMID : 21388661






2 Functional Relationships(s)
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1 Modulation of protein expression of the Bcl-2 family after treatment with metformin and/or cisplatin was determined by Western blotting. Metformin BCL2 apoptosis regulator Homo sapiens
2 Moreover, we established that metformin can induce apoptosis in OVCAR-3 and OVCAR-4 cells by activating caspases 3/7, down-regulating Bcl-2 and Bcl-xL expression, and up-regulating Bax and Bad expression. Metformin BCL2 apoptosis regulator Homo sapiens