Pub. Date : 2011 Jun 1
PMID : 21388661
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of protein expression of the Bcl-2 family after treatment with metformin and/or cisplatin was determined by Western blotting. | Metformin | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Moreover, we established that metformin can induce apoptosis in OVCAR-3 and OVCAR-4 cells by activating caspases 3/7, down-regulating Bcl-2 and Bcl-xL expression, and up-regulating Bax and Bad expression. | Metformin | BCL2 apoptosis regulator | Homo sapiens |