Pub. Date : 2011 Jun
PMID : 21386060
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although elevation of the blood glucose level is a causal adverse effect of treatment with interferon (IFN), the precise underlying molecular mechanism is largely unknown. | Glucose | interferon gamma | Homo sapiens |
| 2 | We examined the effects of type I and type II IFN (IFN-beta and IFN-gamma) on insulin-induced metabolic signaling leading to glucose uptake in 3T3-L1 adipocytes. | Glucose | interferon gamma | Homo sapiens |
| 3 | In contrast, adenovirus-mediated expression of a dominant-negative STAT3 (F-STAT3) attenuated IFN-gamma-induced SOCS3 expression, reduction of IRS-1 protein, and suppression of insulin-induced glucose uptake but did not have any effect on the IFN-beta-mediated SOCS1 expression and inhibition of insulin-induced glucose uptake. | Glucose | interferon gamma | Homo sapiens |
| 4 | In contrast, adenovirus-mediated expression of a dominant-negative STAT3 (F-STAT3) attenuated IFN-gamma-induced SOCS3 expression, reduction of IRS-1 protein, and suppression of insulin-induced glucose uptake but did not have any effect on the IFN-beta-mediated SOCS1 expression and inhibition of insulin-induced glucose uptake. | Glucose | interferon gamma | Homo sapiens |