Title : Effect of genetic polymorphisms related to DNA repair and the xenobiotic pathway on the prognosis and survival of gastric cancer patients.

Pub. Date : 2011 Feb

PMID : 21378360






7 Functional Relationships(s)
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Protein Name
Organism
1 RESULTS: XRCC1 codon 194 Trp carriers (Trp/Trp + Arg/Trp) held a significantly higher risk of venous invasion (OR = 3.76, 95%CI = 1.05-13.51, p = 0.043). Tryptophan X-ray repair cross complementing 1 Homo sapiens
2 RESULTS: XRCC1 codon 194 Trp carriers (Trp/Trp + Arg/Trp) held a significantly higher risk of venous invasion (OR = 3.76, 95%CI = 1.05-13.51, p = 0.043). Tryptophan X-ray repair cross complementing 1 Homo sapiens
3 RESULTS: XRCC1 codon 194 Trp carriers (Trp/Trp + Arg/Trp) held a significantly higher risk of venous invasion (OR = 3.76, 95%CI = 1.05-13.51, p = 0.043). Tryptophan X-ray repair cross complementing 1 Homo sapiens
4 RESULTS: XRCC1 codon 194 Trp carriers (Trp/Trp + Arg/Trp) held a significantly higher risk of venous invasion (OR = 3.76, 95%CI = 1.05-13.51, p = 0.043). Tryptophan X-ray repair cross complementing 1 Homo sapiens
5 A similar trend was also found for the XRCC1 codon 194 Trp/Trp genotype (OR = 2.15, 95% CI = 0.87-5.34, p = 0.099). Tryptophan X-ray repair cross complementing 1 Homo sapiens
6 A similar trend was also found for the XRCC1 codon 194 Trp/Trp genotype (OR = 2.15, 95% CI = 0.87-5.34, p = 0.099). Tryptophan X-ray repair cross complementing 1 Homo sapiens
7 CONCLUSION: XRCC1 codon 194 Trp carrier status is correlated with more aggressive biological behavior of GC, such as venous invasion, and the GSTT1 null genotype is associated with better survival in GC patients. Tryptophan X-ray repair cross complementing 1 Homo sapiens