Pub. Date : 2011 May 30
PMID : 21376710
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, we examined the effect of AKR1B1 knockdown on sugar-induced lens opacification in ex vivo. | Sugars | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 2 | Biochemical analysis of lens homogenates showed that the AKR1B1 activity and sorbitol levels were significantly lower in sugar-treated AKR1B1 knockdown rat lenses as compared to WT rat lenses treated with 50mM glucose. | Sugars | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 3 | Biochemical analysis of lens homogenates showed that the AKR1B1 activity and sorbitol levels were significantly lower in sugar-treated AKR1B1 knockdown rat lenses as compared to WT rat lenses treated with 50mM glucose. | Sugars | aldo-keto reductase family 1 member B1 | Rattus norvegicus |
| 4 | Our results thus confirmed the significance of AKR1B1 in the mediation of sugar-induced lens opacification and indicate the use of AKR1B1 inhibitors in the prevention of cataractogenesis. | Sugars | aldo-keto reductase family 1 member B1 | Rattus norvegicus |