Title : In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities.

Pub. Date : 2011 Jul

PMID : 21365364






1 Functional Relationships(s)
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1 In vitro probe-based high performance liquid chromatography assays were developed to determine CYP2C9-dependent tolbutamide methylhydroxylation, CYP2D6-dependent dextromethorphan O-demethylation and CYP3A4-dependent testosterone 6beta-hydroxylation activities in the presence and absence of AP extracts and andrographolide. Tolbutamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens