Title : CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients.

Pub. Date : 2011 Mar 29

PMID : 21364592






3 Functional Relationships(s)
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1 CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
2 BACKGROUND: We evaluated the association between polymorphisms of cytochrome P450 2A6 (CYP2A6)/excision repair cross-complementation group 1 (ERCC1)/X-ray repair cross-complementing group 1(XRCC1) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
3 CONCLUSION: Polymorphisms of CYP2A6 and ERCC1 19442C>A correlated with the efficacy of S-1/cisplatin. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens