Title : Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.

Pub. Date : 2011 Apr

PMID : 21358420






3 Functional Relationships(s)
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1 METHODS AND RESULTS: Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (PAI-1) gene expression than mice receiving Ang II, N-nitro-L-arginine methyl ester (L-NAME), apelin plus L-NAME or apelin plus Ang II plus L-NAME. NG-Nitroarginine Methyl Ester angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus
2 METHODS AND RESULTS: Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (PAI-1) gene expression than mice receiving Ang II, N-nitro-L-arginine methyl ester (L-NAME), apelin plus L-NAME or apelin plus Ang II plus L-NAME. NG-Nitroarginine Methyl Ester angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus
3 METHODS AND RESULTS: Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (PAI-1) gene expression than mice receiving Ang II, N-nitro-L-arginine methyl ester (L-NAME), apelin plus L-NAME or apelin plus Ang II plus L-NAME. NG-Nitroarginine Methyl Ester angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus