Pub. Date : 2011 Apr 11
PMID : 21356216
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CBD competitively inhibited the activity of CYP3A4, CYP3A5, and HLMs (K(i)=1.00, 0.195, and 6.14 muM, respectively). | Cannabidiol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The lesser inhibitory effects of monomethyl and dimethyl ethers of CBD indicated that the ability of CYP3A inhibition by the cannabinoid attenuated with the number of methylation on the phenolic hydroxyl groups in the resorcinol moiety. | Cannabidiol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | SIGNIFICANCE: This study indicated that CBD most potently inhibited catalytic activity of human CYP3A enzymes, especially CYP3A4 and CYP3A5. | Cannabidiol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | SIGNIFICANCE: This study indicated that CBD most potently inhibited catalytic activity of human CYP3A enzymes, especially CYP3A4 and CYP3A5. | Cannabidiol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | These results suggest that two phenolic hydroxyl groups in the resorcinol moiety of CBD may play an important role in the CYP3A inhibition. | Cannabidiol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |