Pub. Date : 2011 May
PMID : 21349280
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose uptake and oxidation were lower in the renal medulla of the diabetic rats treated with DHEA, and urinary TGF-beta(1), as well as total gluthatione levels, were higher in the diabetic rats treated with DHEA. | Dehydroepiandrosterone | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | DHEA treatment was not beneficial to renal tissue, since it reduced the glomerular filtration rate and renal medulla metabolism, while increasing the urinary excretion of TGF-beta(1) and the compensatory response by the glutathione system, probably due to a mechanism involving a pro-oxidant action or a pro-fibrotic effect of this androgen or its derivatives. | Dehydroepiandrosterone | transforming growth factor, beta 1 | Rattus norvegicus |