Pub. Date : 2011
PMID : 21346370
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Possible association of SLC22A2 polymorphisms with aspirin-intolerant asthma. | Aspirin | solute carrier family 22 member 2 | Homo sapiens |
| 2 | Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells and has been shown to mediate the transport of prostaglandins on the cyclooxygenase pathway which is regulated by aspirin blockage. | Aspirin | solute carrier family 22 member 2 | Homo sapiens |
| 3 | Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells and has been shown to mediate the transport of prostaglandins on the cyclooxygenase pathway which is regulated by aspirin blockage. | Aspirin | solute carrier family 22 member 2 | Homo sapiens |
| 4 | Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells and has been shown to mediate the transport of prostaglandins on the cyclooxygenase pathway which is regulated by aspirin blockage. | Aspirin | solute carrier family 22 member 2 | Homo sapiens |
| 5 | Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells and has been shown to mediate the transport of prostaglandins on the cyclooxygenase pathway which is regulated by aspirin blockage. | Aspirin | solute carrier family 22 member 2 | Homo sapiens |
| 6 | METHODS: To investigate the associations between AIA and genetic polymorphisms of the SLC22A2 gene, 18 variants were genotyped in 163 AIA subjects and 429 aspirin-tolerant asthma (ATA) controls. | Aspirin | solute carrier family 22 member 2 | Homo sapiens |
| 7 | In addition, a polymorphism in intron 4 (rs3912161) and a haplotype (SLC22A2-ht3) showed significantly stronger association signals with the FEV(1) fall rate induced by aspirin provocation in AIA subjects compared with ATA controls (p = 0.004, P(corr) = 0.05). | Aspirin | solute carrier family 22 member 2 | Homo sapiens |
| 8 | CONCLUSION: Our findings suggest that SLC22A2 could be a susceptibility gene for aspirin intolerance in asthmatics. | Aspirin | solute carrier family 22 member 2 | Homo sapiens |