PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21345291-2 2011 In this study, we have investigated the mechanism by which simvastatin inhibits the production of the mediators of inflammation, such as pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1), from fibroblast-like synoviocytes (FLS) derived from patients with RA. Simvastatin 59-70 C-C motif chemokine ligand 2 Homo sapiens 160-194 21345291-2 2011 In this study, we have investigated the mechanism by which simvastatin inhibits the production of the mediators of inflammation, such as pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1), from fibroblast-like synoviocytes (FLS) derived from patients with RA. Simvastatin 59-70 C-C motif chemokine ligand 2 Homo sapiens 196-201 21345291-4 2011 RESULTS: Simvastatin both reduced the secretion of PTX3 and MCP-1 in FLS cultures and inhibited their mRNA expression in these cells. Simvastatin 9-20 C-C motif chemokine ligand 2 Homo sapiens 60-65 21345291-7 2011 CONCLUSIONS: Although simvastatin inhibited the production of PTX3 and MCP-1 in RA FLS, the mechanisms were quite different. Simvastatin 22-33 C-C motif chemokine ligand 2 Homo sapiens 71-76